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KMID : 0370219860300040163
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Yakhak Hoeji
1986 Volume.30 No. 4 p.163 ~ p.168
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Syntheses and Central Nervous Depressant Activities of Piperine Derivatives (Ⅴ)
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都京三/Do, Gyong Sam
林中基/禹源植/李殷芳/Lim, Joong Ki/Woo, Won Sick/Lee, Eun Bang
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Abstract
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Thirteen compounds were synthesized by condensing the N-heterocyclic amines (piperidine, pyrrolidine, morpholine) and secondary aliphatic amines (dimethylamine, diethylamine) with 3, 4-methylenedioxyphenylalkenoic acid chlorides for developing CNS depressants. Among them, N, N-diethyl-3, 4-methylenedioxycinnamamide (IX) and N, N-dimethyl-5- (3, 4-methylenedioxyphenyl) -2, 4-pentadienoic acid amide (XII) exhibited strong activity in antagonism against pentylenetetrazole-induced convulsion, strychnine-induced convulsion and maximal electroshock seizure. N, N-Dimethyl-3, 4-methylenedioxycinnamide (VIII) showed more potent activity in antagonism against strychnine-induced convulsion and maximal electroshock seizure and in the prolongation of hexobarbital sleeping time.
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KEYWORD
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